From Imperial Assassination Cases to Aconite
According to the "Book of Han," during the reign of Emperor Xuan of Han (73–49 BCE), Grand General Huo Guang’s wife wanted her daughter to become empress. She plotted to assassinate the then-empress Xu after her childbirth. She coerced the court physician Chunyu Yan to carry out the assassination during a medication opportunity. Chunyu Yan secretly brought crushed aconite into the palace and mixed it into the pills the empress was supposed to take. Soon after consuming the medicine, the empress felt unwell and soon fell into unconsciousness and died.
Aconite is a highly toxic herb, derived from the lateral tuberous root (child root) of the Ranunculaceae plant Aconitum. It is extremely pungent and hot in nature, containing numerous alkaloids such as aconitine, mesaconitine, and hypaconitine. Pharmacological experiments show that ingesting just 0.2 mg of aconitine can cause poisoning symptoms, including stinging and burning sensations in the mouth and throat, numbness of lips and tongue, difficulty speaking, and tongue stiffness. Severe cases involve nausea, vomiting, abdominal pain, diarrhea, dizziness, muscle rigidity, paroxysmal convulsions, locked jaw, and even ventricular fibrillation or cardiogenic shock leading to death.
Given this, many physicians throughout history have approached its use with caution.
However, according to traditional Chinese medicine theory, toxicity is relative: "Use the right medicine for the right condition." Based on the patient’s "zheng" (syndrome), even highly toxic drugs can be precisely targeted, exerting strong, potent, and swift therapeutic effects. At such times, what is toxic becomes beneficial.
Guided by traditional TCM principles and adhering to syndrome differentiation and treatment, one can harness the clinical efficacy of toxic drugs while effectively preventing their side effects. For example, aconite is a powerful drug with excellent effects in restoring yang and rescuing from collapse, dispelling dampness and cold. Therefore, it has wide clinical applications. We can also combine it with other herbs to enhance efficacy and reduce toxicity. For instance, in the "Si Ni Tang" formula, aconite is paired with dry ginger and roasted licorice to treat deficiency-cold syndromes of the Shaoyin channel. Ginger and licorice both enhance aconite’s ability to restore yang while mitigating its toxicity—a double benefit. Moreover, prolonged boiling reduces aconite’s toxicity; the longer it is cooked, the less toxic it becomes.
Experienced physicians can tame aconite, utilizing its power to revive yang and save lives, recover lost vital energy, and achieve immediate results—truly a masterstroke. The Medical Saint Zhang Zhongjing was particularly skilled at using aconite. In his "Treatise on Cold Damage Disorders," he used aconite in 20 formulas across 37 sections; in "Golden Chamber Essentials," he used it in 11 formulas across 16 sections. Famous prescriptions such as "Aconite Decoction," "Aconite and Rhubarb Pill," and "Golden Chamber Kidney Qi Pill" are proven effective and enduring classics. When used appropriately, their efficacy is exceptional.
The "Compendium of Materia Medica" states: "Aconite travels swiftly, making it the pure yang key herb for all twelve meridians. Externally, it reaches the skin and hair to dispel exterior cold; internally, it reaches the lower jiao to warm chronic cold. It penetrates deeply and broadly, treating any true cold in the zang-fu organs." When combined with other herbs, its effects are even better.
When paired with ephedra, aconite warms the lungs and transforms phlegm, treating lung distension. Clinically, patients with frequent coughing and wheezing, clear and thin sputum, cold back, and white greasy tongue coating—indicating yang deficiency and phlegm stagnation—are treated with Xiao Qing Long Tang (Ephedra, Cinnamon Twig, White Peony, Fine-Needle, Dried Ginger, Licorice, Schisandra, Pinellia) plus aconite, often achieving good results. Aconite, being extremely pungent and hot, not only dispels cold but also dries dampness. Combined with yinchen (a herb for clearing yellowish jaundice), it warms yang and resolves dampness, proving effective for yin-type jaundice. Aconite descends naturally, excelling in replenishing kidney yang and warming bladder qi. When paired with stone fern and other diuretic herbs, it warms yang, promotes qi movement, and facilitates stone expulsion. Paired with rhubarb, aconite warms yang and clears turbidity to treat obstruction and blockage. Rhubarb is a key herb for eliminating turbidity and purging the bowels, but its cold nature may harm kidney yang if used long-term. Aconite, being hot and pungent, disperses cold turbidity and opens obstructions while counteracting rhubarb’s cold nature, preserving its purgative effect. Together, they form a formula that warms and disperses cold turbidity and uses bitter and pungent methods to descend and relieve blockages, effectively resolving obstruction and blockage. Aconite primarily enters the Heart Channel (Shao Yin), greatly replenishing heart yang. Its nature is mobile and not fixed, adept at removing cold pathogens and promoting blood circulation. It is especially effective for treating chest obstruction, offering three benefits in one. Particularly when combined with Sheng Mai Yin (Life-Pulse Drink), it both nourishes pulse and fluids and invigorates yang, enhancing effectiveness.
Modern medical research on aconite reveals it can increase DNA synthesis rates in low-functioning individuals and stimulate the pituitary-adrenal cortex system, regulating sex hormones. It also promotes metabolism, strengthens myocardial contraction, dilates blood vessels, enhances systemic circulation, boosts resistance, and regulates the autonomic nervous system and cold-dispelling functions.
Today, processed aconite is available as an injectable solution for intramuscular injection, used to treat heart failure (congestive heart failure), under medical supervision based on individual conditions.
In winter, stewed lamb with aconite is an excellent tonic for those with deficiency-cold constitution. As the saying goes: "Medicinal supplementation is inferior to dietary supplementation." Aconite supplements yang, while lamb warms the middle and tonifies deficiency—offering both food and medicinal benefits, complementing each other perfectly. The method involves taking 1–2 pounds of lamb, washing and cutting into chunks, placing in a pot with water, adding 30 grams of prepared aconite, along with appropriate seasonings like star anise, fennel, cinnamon bark, licorice, and ginger. Boil vigorously, then simmer gently for 2–3 hours. This slow stewing allows aconitine to hydrolyze and break down, making it safe for consumption. Elderly people with weakness, chronic cough and shortness of breath, low body temperature, and cold extremities benefit greatly from this winter tonic. Note: Do not chew the residue.